The Supreme Court on December 1 recently made a ruling, allowing appointed officials (this includes Cabinet members) to run for elective positions in an election without them being required to resign first from their appointive posts.
This means that if the said official lost for an elective post in an election, he still retains his appointive post. But if he wins, I think he must choose between the two (please correct me on this).
Voting 8-6, the court ruled as unconstitutional provisions in the election laws mandating that appointed officials are deemed resigned once they file a CoC.
The provisions are violative of the equal-protection clause of the Constitution, and discriminate against persons holding appointive positions, the justices asserted.
And since the ruling doesn’t require appointed officials to resign by the start of the election period, Malacañang won’t force Cabinet men to resign, Ermita said. 
In light of this ruling, here is a list of current Cabinet members who have filed their Certificates of Candidacies at COMELEC, and the elective positions they will run for in the 2010 Elections.
- Silvestre Bello III
Secretary to the Cabinet
– for Senator (under Lakas-KAMPI-CMD)
- Eduardo Ermita
– for Congressman, 1st District of Batangas
- Hermogenes Esperon
Head, Presidential Management Staff
– for Congressman, 6th District of Pangasinan
- Agnes Devanadera
– for Congresswoman, 1st District of Quezon
- Arthur Yap
– for Congressman, 3rd District of Bohol
- Augusto Syjuco, Jr.
– for Congressman, 2nd District of Iloilo
- Luis “Chavit “Singson
Deputy National Security Adviser
– for Governor of Ilocos Sur
- Lito Atienza
Environment and Natural Resources Secretary
– for Mayor of Manila
- Avelino Razon
Presidential Adviser on the Peace Process
– for Mayor of Manila
- Edgardo Pamintuan
Presidential Adviser for External Affairs
– for Mayor of Angeles City
- Raul Gonzales
Chief Presidential Legal Counsel
– for Mayor of Iloilo City
Also, here is a list of former Cabinet members under the Arroyo administration who have resigned before or upon filing their CoC’s at COMELEC, and the corresponding elective positions they will run for in the 2010 Elections.
- Gilbert Teodoro
former National Defense Secretary
– for President
- Bayani Fernando
former* MMDA Chairman
– for Vice President (under Bagumbayan Volunteers)
- Ralph Recto
former NEDA Chairman
– for Senator (under the Liberal Party)
- Rolando Andaya, Jr.
– for Congressman, 1st District of Camarines Sur
- Anthony Golez, Jr.
former* Press Undersecretary
– for Congressman, Bacolod City
- Hermogenes Ebdane
former Public Works Secretary
– for Governor of Zambales